Convergent extension: using collective cell migration and cell intercalation to shape embryos

M Tada, CP Heisenberg - Development, 2012 - journals.biologists.com
Development, 2012journals.biologists.com
Body axis elongation represents a common and fundamental morphogenetic process in
development. A key mechanism triggering body axis elongation without additional growth is
convergent extension (CE), whereby a tissue undergoes simultaneous narrowing and
extension. Both collective cell migration and cell intercalation are thought to drive CE and
are used to different degrees in various species as they elongate their body axis. Here, we
provide an overview of CE as a general strategy for body axis elongation and discuss …
Body axis elongation represents a common and fundamental morphogenetic process in development. A key mechanism triggering body axis elongation without additional growth is convergent extension (CE), whereby a tissue undergoes simultaneous narrowing and extension. Both collective cell migration and cell intercalation are thought to drive CE and are used to different degrees in various species as they elongate their body axis. Here, we provide an overview of CE as a general strategy for body axis elongation and discuss conserved and divergent mechanisms underlying CE among different species.
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