[PDF][PDF] TNFR1 signaling and IFN-γ signaling determine whether T cells induce tumor dormancy or promote multistage carcinogenesis

N Müller-Hermelink, H Braumüller, B Pichler, T Wieder… - Cancer cell, 2008 - cell.com
N Müller-Hermelink, H Braumüller, B Pichler, T Wieder, R Mailhammer, K Schaak…
Cancer cell, 2008cell.com
Immune responses may arrest tumor growth by inducing tumor dormancy. The mechanisms
leading to either tumor dormancy or promotion of multistage carcinogenesis by adaptive
immunity are poorly characterized. Analyzing T antigen (Tag)-induced multistage
carcinogenesis in pancreatic islets, we show that Tag-specific CD4+ T cells home selectively
into the tumor microenvironment around the islets, where they either arrest or promote
transition of dysplastic islets into islet carcinomas. Through combined TNFR1 signaling and …
Summary
Immune responses may arrest tumor growth by inducing tumor dormancy. The mechanisms leading to either tumor dormancy or promotion of multistage carcinogenesis by adaptive immunity are poorly characterized. Analyzing T antigen (Tag)-induced multistage carcinogenesis in pancreatic islets, we show that Tag-specific CD4+ T cells home selectively into the tumor microenvironment around the islets, where they either arrest or promote transition of dysplastic islets into islet carcinomas. Through combined TNFR1 signaling and IFN-γ signaling, Tag-specific CD4+ T cells induce antiangiogenic chemokines and prevent αvβ3 integrin expression, tumor angiogenesis, tumor cell proliferation, and multistage carcinogenesis, without destroying Tag-expressing islet cells. In the absence of either TNFR1 signaling or IFN-γ signaling, the same T cells paradoxically promote angiogenesis and multistage carcinogenesis. Thus, tumor-specific T cells can directly survey multistage carcinogenesis through cytokine signaling.
cell.com