[HTML][HTML] The role of α1-fetoprotein transcription factor/LRH-1 in bile acid biosynthesis: a known nuclear receptor activator that can act as a suppressor of bile acid …
A del Castillo-Olivares, JA Campos, WM Pandak… - Journal of Biological …, 2004 - ASBMB
Two key regulatory enzymes in the bile acid biosynthesis pathway are cholesterol 7α-
hydroxylase/CYP7A1 (7α-hydroxylase) and sterol 12α-hydroxylase/CYP8B1 (12α-
hydroxylase). It has been shown previously that hepatocyte nuclear factor-4α (HNF-4) and
the α 1-fetoprotein transcription factor (FTF) are activators of 7α-and 12α-hydroxylase
transcription and that the small heterodimer partner (SHP) suppresses bile acid biosynthesis
by heterodimerizing with FTF. However, the role of FTF in bile acid biosynthesis has been …
hydroxylase/CYP7A1 (7α-hydroxylase) and sterol 12α-hydroxylase/CYP8B1 (12α-
hydroxylase). It has been shown previously that hepatocyte nuclear factor-4α (HNF-4) and
the α 1-fetoprotein transcription factor (FTF) are activators of 7α-and 12α-hydroxylase
transcription and that the small heterodimer partner (SHP) suppresses bile acid biosynthesis
by heterodimerizing with FTF. However, the role of FTF in bile acid biosynthesis has been …