[HTML][HTML] Peroxisome proliferator-activated receptor-γ coactivator-1α activation of CYP7A1 during food restriction and diabetes is still inhibited by small heterodimer …
DJ Shin, TF Osborne - Journal of biological chemistry, 2008 - ASBMB
Cholesterol 7α-hydroxylase (CYP7A1) catalyzes the rate-limiting step in the classic pathway
of hepatic bile acid biosynthesis from cholesterol. During fasting and in type I diabetes,
elevated levels of peroxisome proliferator-activated receptor γ-coactivator-1α (PGC-1α)
induce expression of the Cyp7A1 gene and overexpression of PGC-1α in hepatoma cells
stimulates bile acid synthesis. Using Ad-PGC-1α-RNA interference to induce acute
disruption of PGC-1α in mice, here we show that PGC-1α is necessary for fasting-mediated …
of hepatic bile acid biosynthesis from cholesterol. During fasting and in type I diabetes,
elevated levels of peroxisome proliferator-activated receptor γ-coactivator-1α (PGC-1α)
induce expression of the Cyp7A1 gene and overexpression of PGC-1α in hepatoma cells
stimulates bile acid synthesis. Using Ad-PGC-1α-RNA interference to induce acute
disruption of PGC-1α in mice, here we show that PGC-1α is necessary for fasting-mediated …