Alpha-SMA expression in hepatic stellate cells and quantitative analysis of hepatic fibrosis in cirrhosis and in recurrent chronic hepatitis after liver transplantation

G Carpino, S Morini, SG Corradini, A Franchitto… - Digestive and liver …, 2005 - Elsevier
BACKGROUND.: The alpha isotype of actin expressed by hepatic stellate cells reflects their
activation to myofibroblast-like cell and has been directly related to experimental liver
fibrogenesis, and indirectly to human fibrosis in chronic liver disease. AIMS.: To evaluate the
changes in distribution and percentage of alpha-smooth muscle actin-positive hepatic
stellate cells and the correlation with the degree of the fibrosis in cirrhotic livers, as well as in
patients with recurrent HCV chronic hepatitis after liver transplantation. METHODS.: Human …