Dietary electrolyte–driven responses in the renal wnk kinase pathway in vivo
M O'Reilly, E Marshall, T MacGillivray… - Journal of the …, 2006 - journals.lww.com
WNK1 and WNK4 are unusual serine/threonine kinases with atypical positioning of the
catalytic active-site lysine (WNK: With-No-K [lysine]). Mutations in these WNK kinase genes
can cause familial hyperkalemic hypertension (FHHt), an autosomal dominant, hypertensive,
hyperkalemic disorder, implicating this novel WNK pathway in normal regulation of BP and
electrolyte balance. Full-length (WNK1-L) and short (WNK1-S) kinase-deficient WNK1
isoforms previously have been identified. Importantly, WNK1-S is overwhelmingly …
catalytic active-site lysine (WNK: With-No-K [lysine]). Mutations in these WNK kinase genes
can cause familial hyperkalemic hypertension (FHHt), an autosomal dominant, hypertensive,
hyperkalemic disorder, implicating this novel WNK pathway in normal regulation of BP and
electrolyte balance. Full-length (WNK1-L) and short (WNK1-S) kinase-deficient WNK1
isoforms previously have been identified. Importantly, WNK1-S is overwhelmingly …