[HTML][HTML] WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters
J Rinehart, N Vázquez, KT Kahle, CA Hodson… - Journal of Biological …, 2011 - ASBMB
NKCC1 and KCC2, related cation-chloride cotransporters (CCC), regulate cell volume and γ-
aminobutyric acid (GABA)-ergic neurotranmission by modulating the intracellular
concentration of chloride [Cl−]. These CCCs are oppositely regulated by serine-threonine
phosphorylation, which activates NKCC1 but inhibits KCC2. The kinase (s) that performs this
function in the nervous system are not known with certainty. WNK1 and WNK4, members of
the WNK (with no lysine [K]) kinase family, either directly or via the downstream SPAK/OSR1 …
aminobutyric acid (GABA)-ergic neurotranmission by modulating the intracellular
concentration of chloride [Cl−]. These CCCs are oppositely regulated by serine-threonine
phosphorylation, which activates NKCC1 but inhibits KCC2. The kinase (s) that performs this
function in the nervous system are not known with certainty. WNK1 and WNK4, members of
the WNK (with no lysine [K]) kinase family, either directly or via the downstream SPAK/OSR1 …