[HTML][HTML] Importance of CCL2-CCR2A/2B signaling for monocyte migration into spheroids of breast cancer-derived fibroblasts
M Ksiazkiewicz, E Gottfried, M Kreutz, M Mack… - Immunobiology, 2010 - Elsevier
A considerable fraction of tumor-associated macrophages (TAM) is located in the fibroblast-
rich stromal compartment of desmoplastic breast carcinoma. We analyzed the migratory
activity of blood monocytes (MO), the precursor cells of TAM, into 3-D cultures of carcinoma
cells and fibroblasts from breast tumor origin. MO migration into breast tumor spheroids was
highly variable: Hs578T spheroids showed high MO infiltration rates, T47D cultures were
intermediate, whereas BT549, BT474 and MCF-7 spheroids were poorly infiltrated. MO …
rich stromal compartment of desmoplastic breast carcinoma. We analyzed the migratory
activity of blood monocytes (MO), the precursor cells of TAM, into 3-D cultures of carcinoma
cells and fibroblasts from breast tumor origin. MO migration into breast tumor spheroids was
highly variable: Hs578T spheroids showed high MO infiltration rates, T47D cultures were
intermediate, whereas BT549, BT474 and MCF-7 spheroids were poorly infiltrated. MO …