Myeloid-derived suppressor cells in cancer: therapeutic, predictive, and prognostic implications
CM Diaz-Montero, J Finke, AJ Montero - Seminars in oncology, 2014 - Elsevier
Immune evasion is a hallmark of cancer. While there are multiple different mechanisms that
cancer cells employ, myeloid-derived suppressor cells (MDSCs) are one of the key drivers of
tumor-mediated immune evasion. MDSCs begin as myeloid cells recruited to the tumor
microenvironment, where they are transformed into potent immunosuppressive cells.
However, our understanding of the clinical relevance of MDSCs in cancer patients has
significantly lagged behind the preclinical literature in part due to the absence of a cognate …
cancer cells employ, myeloid-derived suppressor cells (MDSCs) are one of the key drivers of
tumor-mediated immune evasion. MDSCs begin as myeloid cells recruited to the tumor
microenvironment, where they are transformed into potent immunosuppressive cells.
However, our understanding of the clinical relevance of MDSCs in cancer patients has
significantly lagged behind the preclinical literature in part due to the absence of a cognate …