Iron overload promotes Cyclin D1 expression and alters cell cycle in mouse hepatocytes

MB Troadec, B Courselaud, L Détivaud… - Journal of …, 2006 - Elsevier
BACKGROUND/AIMS: Patients exhibiting hepatic iron overload frequently develop
hepatocellular carcinoma. An impaired expression of hepatic genes could be involved in this
phenomenon. Our aim was to identify, during iron overload, hepatic genes involved in cell
cycle which are misregulated. RESULTS: Mouse iron overload was obtained by carbonyl–
iron supplementation or iron–dextran injection. As expected, liver iron overload was
associated to both hepatomegaly and hepatocyte polyploidisation. Hepatic gene expression …