The role of KLF6 and its splice variants in cancer therapy
The Krüppel-like zinc finger transcription factor (KLF6) gene encodes a family of proteins
generated through alternative splicing involved in the regulation of cancer development and
progression. Alternative splicing of the KLF6 gene results in the production of at least four
alternatively spliced isoforms, two of which are extensively discussed in this review. The full
length form of the KLF6 gene is a tumor suppressor gene that is frequently inactivated by
loss of heterozygozity (LOH), somatic mutation, and/or decreased expression in human …
generated through alternative splicing involved in the regulation of cancer development and
progression. Alternative splicing of the KLF6 gene results in the production of at least four
alternatively spliced isoforms, two of which are extensively discussed in this review. The full
length form of the KLF6 gene is a tumor suppressor gene that is frequently inactivated by
loss of heterozygozity (LOH), somatic mutation, and/or decreased expression in human …