[HTML][HTML] Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes
A Guilherme, NA Soriano, PS Furcinitti… - Journal of Biological …, 2004 - ASBMB
Insulin stimulates glucose transport in muscle and adipose tissues by recruiting intracellular
membrane vesicles containing the glucose transporter GLUT4 to the plasma membrane.
The mechanisms involved in the biogenesis of these vesicles and their translocation to the
cell surface are poorly understood. Here, we report that an Eps15 homology (EH) domain-
containing protein, EHD1, controls the normal perinuclear localization of GLUT4-containing
membranes and is required for insulin-stimulated recycling of these membranes in cultured …
membrane vesicles containing the glucose transporter GLUT4 to the plasma membrane.
The mechanisms involved in the biogenesis of these vesicles and their translocation to the
cell surface are poorly understood. Here, we report that an Eps15 homology (EH) domain-
containing protein, EHD1, controls the normal perinuclear localization of GLUT4-containing
membranes and is required for insulin-stimulated recycling of these membranes in cultured …