Beneficial effect of cigarette smoking cessation on fibrin clot properties
E Stępień, T Miszalski-Jamka, P Kapusta… - Journal of thrombosis …, 2011 - Springer
E Stępień, T Miszalski-Jamka, P Kapusta, G Tylko, M Pasowicz
Journal of thrombosis and thrombolysis, 2011•SpringerTo examine the associations between cigarette smoking and preferable clot properties.
Plasma fibrin clots from 21 randomly selected current smokers (n= 7), former smokers (n= 7)
and non-smokers (n= 7) were analyzed, using scanning electron microscopy (SEM). With
the use of the turbidimetric clotting and lysis assay in plasma, the maximum absorbance
(MaxAbs C, MaxAbs L) was measured and lysis time (Lys 50%) was calculated. Smoking
cessation significantly influenced fibrin fiber branching and density. Median fiber diameter …
Plasma fibrin clots from 21 randomly selected current smokers (n= 7), former smokers (n= 7)
and non-smokers (n= 7) were analyzed, using scanning electron microscopy (SEM). With
the use of the turbidimetric clotting and lysis assay in plasma, the maximum absorbance
(MaxAbs C, MaxAbs L) was measured and lysis time (Lys 50%) was calculated. Smoking
cessation significantly influenced fibrin fiber branching and density. Median fiber diameter …
Abstract
To examine the associations between cigarette smoking and preferable clot properties. Plasma fibrin clots from 21 randomly selected current smokers (n = 7), former smokers (n = 7) and non-smokers (n = 7) were analyzed, using scanning electron microscopy (SEM). With the use of the turbidimetric clotting and lysis assay in plasma, the maximum absorbance (MaxAbsC, MaxAbsL) was measured and lysis time (Lys50%) was calculated. Smoking cessation significantly influenced fibrin fiber branching and density. Median fiber diameter was not changed. Lys50% was the highest in current smokers and was reduced in former smokers to the non-smoker level (2120 ± 385 versus 1771 ± 122 and 1724 ± 272 s; P = 0.04). Smoking cessation improves fibrin clot architecture which results in the lesser resistance to lysis.
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