Independent clonal origin of multiple uterine leiomyomas that was determined by X chromosome inactivation and microsatellite analysis
RA Canevari, A Pontes, FE Rosa, CA Rainho… - American journal of …, 2005 - Elsevier
OBJECTIVE: In an attempt to clarify the clonality and genetic relationships that are involved
in the tumorigenesis of uterine leiomyomas, we used a total of 43 multiple leiomyomas from
14 patients and analyzed the allelic status with 15 microsatellite markers and X chromosome
inactivation analysis. STUDY DESIGN: We have used a set of 15 microsatellite
polymorphism markers mapped on 3q, 7p, 11, and 15q by automated analysis. The X
chromosome inactivation was evaluated by the methylation status of the X-linked androgen …
in the tumorigenesis of uterine leiomyomas, we used a total of 43 multiple leiomyomas from
14 patients and analyzed the allelic status with 15 microsatellite markers and X chromosome
inactivation analysis. STUDY DESIGN: We have used a set of 15 microsatellite
polymorphism markers mapped on 3q, 7p, 11, and 15q by automated analysis. The X
chromosome inactivation was evaluated by the methylation status of the X-linked androgen …