Cytogenetics of Bone and Soft Tissue Tumors [1]. In view of the remarkable developments in
this field since 1994, both in the cytogenetic and particularly in the molecular genetic
aspects of these tumors, it seemed logical to bring the above book up to date. In this issue
and in subsequent issues of Cancer Genetics and Cytogenetics, updates corresponding to
various chapters or sections in the book and reviews of the cytogenetics and molecular
genetics on the small number of relevant bone and soft tissue tumors and conditions not …

In this Update, the cytogenetic and molecular genetic findings in osteosarcoma (OS) and
some related tumors published since our book appeared in 1994 [1] will be presented and
reviewed. Osteosarcoma is uncommon (ie, 2.4% of all childhood cancers), with∼ 1000 new
cases diagnosed yearly in the United States. It is, however, the most common
nonhematologic malignant tumor of bone in children (56% of all malignant tumors of bone)
and adults [2]. The peak incidence of OS occurs in the second decade (5.6 per million …

The present Update on synovial sarcoma (SS) follows the pattern of previous ones in that it
presents findings related to this tumor which have appeared since 1994 when our book was
published [1]. As is true of other tumors, most of the information on the genetic aspects of SS
has been of molecular nature, outstripping that supplied by conventional cytogenetics.
Synovial sarcoma is an aggressive tumor that accounts for about 10% of soft tissue tumors,
frequently (in 90% of the cases) arising in the limbs adjacent to joints and tendons of …