[HTML][HTML] Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death
P Hu, Z Han, AD Couvillon, JH Exton - Journal of Biological Chemistry, 2004 - ASBMB
Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of many
diseases and in cancer therapy. Although the unfolded protein response is known to
alleviate ER stress by reducing the accumulation of misfolded proteins, the exact survival
elements and their downstream signaling pathways that directly counteract ER stress-
stimulated apoptotic signaling remain elusive. Here, we have shown that endogenous Akt
and ERK are rapidly activated and act as downstream effectors of phosphatidylinositol 3 …
diseases and in cancer therapy. Although the unfolded protein response is known to
alleviate ER stress by reducing the accumulation of misfolded proteins, the exact survival
elements and their downstream signaling pathways that directly counteract ER stress-
stimulated apoptotic signaling remain elusive. Here, we have shown that endogenous Akt
and ERK are rapidly activated and act as downstream effectors of phosphatidylinositol 3 …