Neutrophils contain an assembly of granules destined for regulated secretion, each granule
type with distinct constituents formed before terminal differentiation. The earliest granules
are designated azurophil (primary), followed in time by specific (secondary), and gelatinase
granules as well as secretory vesicles. Transcription factors regulate the genes for the
granule proteins to ensure that expression of the gene products to be stored in different
organelles is separated in time. Similar to lysosomal enzymes, many granule proteins, in …