ELANE mutations in cyclic and severe congenital neutropenia: genetics and pathophysiology

MS Horwitz, SJ Corey, HL Grimes… - Hematology/Oncology …, 2013 - hemonc.theclinics.com
Normal neutrophil counts in peripheral blood typically range between 1500 to 8500 cells/mL
after the age of 1 year, 1 although they vary among individuals from different parts of the
world and at different ages.“Benign ethnic neutropenia” has been used to describe the
normally lower neutrophil levels observed in certain populations, including African
Americans and some Middle Eastern groups. 2 Within individuals, neutrophil counts
fluctuate in response to environmental and host factors 3 and to circadian cycles. 4 a …