[HTML][HTML] Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells

Z Ji, FC Mei, J Xie, X Cheng - Journal of Biological Chemistry, 2007 - ASBMB
Hedgehog (Hh) signaling is deregulated in multiple human cancers including pancreatic
ductal adenocarcinoma (PDA). Because KRAS mutation represents one of the earliest
genetic alterations and occurs almost universally in PDA, we hypothesized that oncogenic
KRAS promotes pancreatic tumorigenesis in part through activation of the Hh pathway.
Here, we report that oncogenic KRAS activates hedgehog signaling in PDA cells, utilizing a
downstream effector pathway mediated by RAF/MEK/MAPK but not phosphatidylinositol 3 …