Early breathing defects after moderate hypoxia or hypercapnia in a mouse model of Rett syndrome
N Voituron, S Zanella, C Menuet, M Dutschmann… - Respiratory physiology …, 2009 - Elsevier
Rett syndrome (RTT) is a rare neurodevelopmental disease caused by mutations in the
transcriptional repressor methyl-CpG-binding protein 2 (MeCP2) and accompanied by
complex symptoms, including erratic breathing and life-threatening apnoeas. In Mecp2-
deficient male mice (Mecp2−/y), breathing is normal at birth but becomes altered after
postnatal day 30 (P30), with erratic rhythm and apnoeas aggravating until death at around
P60. Using plethysmography, we analyzed breathing of unrestrained wild type mice and …
transcriptional repressor methyl-CpG-binding protein 2 (MeCP2) and accompanied by
complex symptoms, including erratic breathing and life-threatening apnoeas. In Mecp2-
deficient male mice (Mecp2−/y), breathing is normal at birth but becomes altered after
postnatal day 30 (P30), with erratic rhythm and apnoeas aggravating until death at around
P60. Using plethysmography, we analyzed breathing of unrestrained wild type mice and …