Derivation of patient-specific induced pluripotent stem cells (iPSCs) opens a new avenue for
future applications of regenerative medicine. However, before iPSCs can be used in a
clinical setting, it is critical to validate their in vivo fate following autologous transplantation.
Thus far, preclinical studies have been limited to small animals and have yet to be
conducted in large animals that are physiologically more similar to humans. In this study, we
report the first autologous transplantation of iPSCs in a large animal model through the …