The role of type I interferon production by dendritic cells in host defense
P Fitzgerald-Bocarsly, D Feng - Biochimie, 2007 - Elsevier
Type I interferons (IFN) and dendritic cells (DC) share an overlapping history, with rapidly
accumulating evidence for vital roles for both production of type 1 IFN by DC and the
interaction of this IFN both with DC and components of the innate and adaptive immune
responses. Within the innate immune response, the plasmacytoid DC (pDC) are the
“professional” IFN producing cells, expressing specialized toll-like receptors (TLR7 and-9)
and high constitutive expression of IRF-7 that allow them to respond to viruses with rapid …
accumulating evidence for vital roles for both production of type 1 IFN by DC and the
interaction of this IFN both with DC and components of the innate and adaptive immune
responses. Within the innate immune response, the plasmacytoid DC (pDC) are the
“professional” IFN producing cells, expressing specialized toll-like receptors (TLR7 and-9)
and high constitutive expression of IRF-7 that allow them to respond to viruses with rapid …