Serum response factor (SRF), is a crucial transcription factor for murine embryonic
development and for the function of muscle cells and neurons. Gene expression data show
that SRF and its transcriptional cofactors are also expressed in lymphocyte precursors and
mature lymphocytes. However, the role of SRF in lymphocyte development has not been
addressed in vivo so far, attributed in part to early embryonic lethality of conventional Srf-null
mice. To determine the in vivo role of SRF in developing lymphocytes, we specifically …