[HTML][HTML] SM-20, EGL-9, and the EGLN family of hypoxia-inducible factor prolyl hydroxylases
RS Freeman, DM Hasbani, EA Lipscomb, JA Straub… - Molecules and …, 2003 - Elsevier
Key to the transduction of signals from the environment to the cell nucleus are enzymes that
post-translationally modify proteins. Modifications such as protein phosphorylation have
long been known to regulate protein interactions, stability, and localization, as well as
enzyme activity. Recent investigations into how cells respond to varying oxygen levels have
identified a new mechanism for regulating signal transduction involving the post-
translational hydroxylation of proline. The enzymes that catalyze this reaction comprise a …
post-translationally modify proteins. Modifications such as protein phosphorylation have
long been known to regulate protein interactions, stability, and localization, as well as
enzyme activity. Recent investigations into how cells respond to varying oxygen levels have
identified a new mechanism for regulating signal transduction involving the post-
translational hydroxylation of proline. The enzymes that catalyze this reaction comprise a …