An update on the rotenone models of Parkinson's disease: their ability to reproduce the features of clinical disease and model gene–environment interactions
ME Johnson, L Bobrovskaya - Neurotoxicology, 2015 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disorder that is
characterized by two major neuropathological hallmarks: the degeneration of dopaminergic
neurons in the substantia nigra (SN) and the presence of Lewy bodies in the surviving SN
neurons, as well as other regions of the central and peripheral nervous system. Animal
models have been invaluable tools for investigating the underlying mechanisms of the
pathogenesis of PD and testing new potential symptomatic, neuroprotective and …
characterized by two major neuropathological hallmarks: the degeneration of dopaminergic
neurons in the substantia nigra (SN) and the presence of Lewy bodies in the surviving SN
neurons, as well as other regions of the central and peripheral nervous system. Animal
models have been invaluable tools for investigating the underlying mechanisms of the
pathogenesis of PD and testing new potential symptomatic, neuroprotective and …