Evidence for Efficient Vertical Transfer of Maternal HIV-1 Envelope–Specific Neutralizing Antibodies but No Association of Such Antibodies With Reduced Infant …

MM Omenda, C Milligan, K Odem-Davis… - JAIDS Journal of …, 2013 - journals.lww.com
MM Omenda, C Milligan, K Odem-Davis, R Nduati, BA Richardson, J Lynch, G John-Stewart
JAIDS Journal of Acquired Immune Deficiency Syndromes, 2013journals.lww.com
Little is known about the efficiency of vertical transfer of HIV-1–specific antibodies. Antibody
levels in plasma from 60 mother–infant pairs near the time of birth, including 14 breast-
feeding transmission pairs, were compared. The envelope-binding titers were strongly
correlated (r= 0.91, P< 0.0001) and similar (1.4-fold greater in maternal plasma) between a
mother and her corresponding infant as were the neutralizing antibody (Nab) levels (r= 0.80,
P< 0.0001; 1.3-fold higher), suggesting efficient transfer. There was no significant difference …
Abstract
Little is known about the efficiency of vertical transfer of HIV-1–specific antibodies. Antibody levels in plasma from 60 mother–infant pairs near the time of birth, including 14 breast-feeding transmission pairs, were compared. The envelope-binding titers were strongly correlated (r= 0.91, P< 0.0001) and similar (1.4-fold greater in maternal plasma) between a mother and her corresponding infant as were the neutralizing antibody (Nab) levels (r= 0.80, P< 0.0001; 1.3-fold higher), suggesting efficient transfer. There was no significant difference in Nab responses between transmitting and nontransmitting mothers, although there was a trend for transmitting mothers to have higher HIV-1–specific Nabs.
Lippincott Williams & Wilkins