Induction of wasting disease in SCID mice by the transfer of normal CD4+/CD45RBhi T cells and the regulation of this autoreactivity by CD4+/CD45RBlo T cells
PJ Morrissey, K Charrier - Research in immunology, 1994 - Elsevier
SCID mice injected with coisogenic CD4+/CD45RB hi lymph node T cells from normal
donors develop a wasting disease that is due to hyperplasia of the intestinal epithelium.
SCID mice injected with purified lymph node CD4+ T cells or CD4+/CD45RB lo T cells do
not develop the disease. In addition, mixture of the CD4+/CD45RB lo T cells with equal
numbers of CD4+/CD45RB hi T cells inhibits the development of disease. SCID mice that
were reconstituted with CD45RB hi T cells with active disease were treated with oral …
donors develop a wasting disease that is due to hyperplasia of the intestinal epithelium.
SCID mice injected with purified lymph node CD4+ T cells or CD4+/CD45RB lo T cells do
not develop the disease. In addition, mixture of the CD4+/CD45RB lo T cells with equal
numbers of CD4+/CD45RB hi T cells inhibits the development of disease. SCID mice that
were reconstituted with CD45RB hi T cells with active disease were treated with oral …