Two mitosis-specific antibodies, MPM-2 and phospho-histone H3 (Ser28), allow rapid and precise determination of mitotic activity

C Tapia, H Kutzner, T Mentzel, S Savic… - The American journal …, 2006 - journals.lww.com
Mitotic figure (MF) counting is important in the evaluation of many tumor types. Inadequate
fixation, crush artefacts, the presence of many apoptoses, or the rarity of MFs in a given
lesion can make the determination of the mitotic index a very time-consuming or even
impossible task, especially for novices. We evaluated the potential of the two commercially
available mitotic markers MPM-2 and Phospho-Histone H3 Ser28 (PHH3) for improving
mitotic counting. Formalin-fixed tissue of 1 lymphoma, 19 epithelial, 25 mesenchymal, and …