[HTML][HTML] The selenium-rich C-terminal domain of mouse selenoprotein P is necessary for the supply of selenium to brain and testis but not for the maintenance of …
KE Hill, J Zhou, LM Austin, AK Motley, AJL Ham… - Journal of Biological …, 2007 - ASBMB
Selenoprotein P (Sepp1) has two domains with respect to selenium content: the N-terminal,
selenium-poor domain and the C-terminal, selenium-rich domain. To assess domain
function, mice with deletion of the C-terminal domain have been produced and compared
with Sepp1–/–and Sepp1+/+ mice. All mice studied were males fed a semipurified diet with
defined selenium content. The Sepp1 protein in the plasma of mice with the C-terminal
domain deleted was determined by mass spectrometry to terminate after serine 239 and …
selenium-poor domain and the C-terminal, selenium-rich domain. To assess domain
function, mice with deletion of the C-terminal domain have been produced and compared
with Sepp1–/–and Sepp1+/+ mice. All mice studied were males fed a semipurified diet with
defined selenium content. The Sepp1 protein in the plasma of mice with the C-terminal
domain deleted was determined by mass spectrometry to terminate after serine 239 and …