Oxidative stress in ulcerative colitis-associated carcinogenesis

A Roessner, D Kuester, P Malfertheiner… - … -Research and practice, 2008 - Elsevier
Oxidative stress is defined as an imbalance between generation of reactive oxygen species
(ROS) and decreased antioxidant defense systems. Oxidative stress develops particularly in
inflammatory reactions because the inflammatory cells, neutrophils, and macrophages
produce large amounts of ROS. It has been known for a long time that oxidative stress in
inflamed tissue can pave the way for malignant tumors, and that it is a major pathogenetic
factor for the well-established correlation between inflammatory diseases and cancer …