Cloning of a delta opioid receptor by functional expression
CJ Evans, DE Keith Jr, H Morrison, K Magendzo… - Science, 1992 - science.org
CJ Evans, DE Keith Jr, H Morrison, K Magendzo, RH Edwards
Science, 1992•science.orgOpiate drugs have potent analgesic and addictive properties. These drugs interact with
receptors that also mediate the response to endogenous opioid peptide ligands. However,
the receptors for opioids have eluded definitive molecular characterization. By transient
expression in COS cells and screening with an iodinated analog of the opioid peptide
enkephalin, a complementary DNA clone encoding a functional δ opioid receptor has been
identified. The sequence shows homology to G protein-coupled receptors, in particular the …
receptors that also mediate the response to endogenous opioid peptide ligands. However,
the receptors for opioids have eluded definitive molecular characterization. By transient
expression in COS cells and screening with an iodinated analog of the opioid peptide
enkephalin, a complementary DNA clone encoding a functional δ opioid receptor has been
identified. The sequence shows homology to G protein-coupled receptors, in particular the …
Opiate drugs have potent analgesic and addictive properties. These drugs interact with receptors that also mediate the response to endogenous opioid peptide ligands. However, the receptors for opioids have eluded definitive molecular characterization. By transient expression in COS cells and screening with an iodinated analog of the opioid peptide enkephalin, a complementary DNA clone encoding a functional δ opioid receptor has been identified. The sequence shows homology to G protein-coupled receptors, in particular the receptors for somatostatin, angiotensin, and interleukin-8.
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