Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: stimulus specificity, behavioral parameters and opioid receptor …
MJ Iadarola, LS Brady, G Draisci, R Dubner - Pain, 1988 - Elsevier
The stimulus specificity for enhancement of dynorphin gene expression in rat spinal cord
was studied by combined measurements of the peptide dynorphin A 1–8 and
preprodynorphin mRNA levels during peripheral inflammation induced by several agents.
The density of kappa receptors, the putative receptor for dynorphin peptides, was examined
using receptor binding with autoradiographic visualization. Mu and delta receptor classes
were also studied. All inflammatory agents tested (carrageenan, phorbol ester, yeast and …
was studied by combined measurements of the peptide dynorphin A 1–8 and
preprodynorphin mRNA levels during peripheral inflammation induced by several agents.
The density of kappa receptors, the putative receptor for dynorphin peptides, was examined
using receptor binding with autoradiographic visualization. Mu and delta receptor classes
were also studied. All inflammatory agents tested (carrageenan, phorbol ester, yeast and …