Co-induction of heme oxygenase-1 and peroxiredoxin I in astrocytes and microglia around hemorrhagic region in the rat brain
K Nakaso, M Kitayama, E Mizuta, H Fukuda, T Ishii… - Neuroscience …, 2000 - Elsevier
K Nakaso, M Kitayama, E Mizuta, H Fukuda, T Ishii, K Nakashima, K Yamada
Neuroscience letters, 2000•ElsevierHeme [none1] oxygenase-1 (HO-1) and peroxiredoxin I (PrxI) are known to be oxidative
stress-and heme-related proteins. The antioxidant activity of PrxI is inhibited by heme,
therefore co-expression of HO-1 and PrxI is considered to be a reasonable mechanism to
maintain its antioxidative function. Immunoblotting demonstrated that HO-1 and PrxI were
induced around the hemorrhagic region. Immunohistochemical studies revealed that, in
acute phase, HO-1 and PrxI were induced primarily in microglia. In the subacute and chronic …
stress-and heme-related proteins. The antioxidant activity of PrxI is inhibited by heme,
therefore co-expression of HO-1 and PrxI is considered to be a reasonable mechanism to
maintain its antioxidative function. Immunoblotting demonstrated that HO-1 and PrxI were
induced around the hemorrhagic region. Immunohistochemical studies revealed that, in
acute phase, HO-1 and PrxI were induced primarily in microglia. In the subacute and chronic …
Heme[none1] oxygenase-1 (HO-1) and peroxiredoxin I (PrxI) are known to be oxidative stress- and heme-related proteins. The antioxidant activity of PrxI is inhibited by heme, therefore co-expression of HO-1 and PrxI is considered to be a reasonable mechanism to maintain its antioxidative function. Immunoblotting demonstrated that HO-1 and PrxI were induced around the hemorrhagic region. Immunohistochemical studies revealed that, in acute phase, HO-1 and PrxI were induced primarily in microglia. In the subacute and chronic phase, the immunoreactivity of HO-1 and PrxI in astrocytes was the most intense. These data are the first to demonstrate co-induction of HO-1 and PrxI in the brain. Our results suggest that HO-1 and PrxI are localized in a similar manner to assure the antioxidant activity of PrxI under stress conditions associated with intracerebral hemorrhage.
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