CORM-3, a carbon monoxide-releasing molecule, alters the inflammatory response and reduces brain damage in a rat model of hemorrhagic stroke
A Yabluchanskiy, P Sawle… - Critical care …, 2012 - journals.lww.com
Objective: Intracerebral hemorrhage is accompanied by a pronounced inflammatory
response that mediates brain damage but is also essential for the tissue reparative process.
We assessed the effect of CORM-3, a water-soluble carbon monoxide-releasing molecule
possessing anti-inflammatory properties, on inflammation and brain injury after intracerebral
hemorrhage. Design: In vivo and in vitro laboratory study. Setting: Research laboratory.
Subjects: Male Sprague-Dawley rats, 250–350 g. Interventions: A model of collagenase …
response that mediates brain damage but is also essential for the tissue reparative process.
We assessed the effect of CORM-3, a water-soluble carbon monoxide-releasing molecule
possessing anti-inflammatory properties, on inflammation and brain injury after intracerebral
hemorrhage. Design: In vivo and in vitro laboratory study. Setting: Research laboratory.
Subjects: Male Sprague-Dawley rats, 250–350 g. Interventions: A model of collagenase …