The cell biology of the unfolded protein response
JA Diehl, SY Fuchs, C Koumenis - Gastroenterology, 2011 - Elsevier
JA Diehl, SY Fuchs, C Koumenis
Gastroenterology, 2011•ElsevierThe unfolded protein response (UPR) is an ensemble of signal transduction pathways that
respond to perturbations in the oxidative, pro-folding environment of the endoplasmic
reticulum. During the past decade, ongoing research implicated these pathways in
maintaining homeostasis of cells and organisms exposed to various stresses. Herein, we
highlight recent findings regarding the functional role of the UPR in both normal and
pathophysiologic processes.
respond to perturbations in the oxidative, pro-folding environment of the endoplasmic
reticulum. During the past decade, ongoing research implicated these pathways in
maintaining homeostasis of cells and organisms exposed to various stresses. Herein, we
highlight recent findings regarding the functional role of the UPR in both normal and
pathophysiologic processes.
The unfolded protein response (UPR) is an ensemble of signal transduction pathways that respond to perturbations in the oxidative, pro-folding environment of the endoplasmic reticulum. During the past decade, ongoing research implicated these pathways in maintaining homeostasis of cells and organisms exposed to various stresses. Herein, we highlight recent findings regarding the functional role of the UPR in both normal and pathophysiologic processes.
Elsevier