CD34+ hemopoietic progenitor cells are potent effectors of allergic inflammation
Z Allakhverdi, MR Comeau, DE Smith, D Toy… - Journal of Allergy and …, 2009 - Elsevier
BACKGROUND: In steady state, hemopoietic progenitors constantly egress from the bone
marrow (BM) into the blood and circulate through the peripheral tissues. In allergic diseases,
the BM releases increased numbers of CD34+ progenitor cells that migrate to the site of
allergic inflammation, where they differentiate into tissue-dwelling and classic effector cells
of allergy, such as mast cells, eosinophils, and basophils. OBJECTIVE: To examine whether
peripheral blood CD34+ cells in addition to being progenitors may also directly function as …
marrow (BM) into the blood and circulate through the peripheral tissues. In allergic diseases,
the BM releases increased numbers of CD34+ progenitor cells that migrate to the site of
allergic inflammation, where they differentiate into tissue-dwelling and classic effector cells
of allergy, such as mast cells, eosinophils, and basophils. OBJECTIVE: To examine whether
peripheral blood CD34+ cells in addition to being progenitors may also directly function as …