Multiple sclerosis. Updated risks for relatives
AD Sadovnick, PA Baird, RH Ward… - American journal of …, 1988 - Wiley Online Library
AD Sadovnick, PA Baird, RH Ward, JM Optiz, JF Reynolds
American journal of medical genetics, 1988•Wiley Online LibraryTwo important characteristics of multiple sclerosis (MS) are familial clustering and a variable
age of onset. There is increasing evidence for a genetically influenced susceptibility in MS.
Because of this, patients and their relatives are increasingly asking about the risk for
relatives of developing MS. In the MS Clinic in Vancouver, genetic histories are taken
routinely for all patients and are updated annually. Patients do not attend the clinic
specifically to participate in genetic studies, which could result in over‐representation of …
age of onset. There is increasing evidence for a genetically influenced susceptibility in MS.
Because of this, patients and their relatives are increasingly asking about the risk for
relatives of developing MS. In the MS Clinic in Vancouver, genetic histories are taken
routinely for all patients and are updated annually. Patients do not attend the clinic
specifically to participate in genetic studies, which could result in over‐representation of …
Abstract
Two important characteristics of multiple sclerosis (MS) are familial clustering and a variable age of onset. There is increasing evidence for a genetically influenced susceptibility in MS. Because of this, patients and their relatives are increasingly asking about the risk for relatives of developing MS.
In the MS Clinic in Vancouver, genetic histories are taken routinely for all patients and are updated annually. Patients do not attend the clinic specifically to participate in genetic studies, which could result in over‐representation of familial cases.
Data were available for 815 MS index cases and 11,345 of their relatives. Age‐specific MS risks were calculated for first‐, second‐, and third‐degree relatives of probands and are presented in an easy‐reference format. In general, first‐degree relatives of probands have a risk that is 30–50 times greater than the 0.1% risk for the general population.
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