[HTML][HTML] MicroRNA control in the immune system: basic principles

C Xiao, K Rajewsky - Cell, 2009 - cell.com
C Xiao, K Rajewsky
Cell, 2009cell.com
MicroRNA (miRNA) control has emerged as a critical regulatory principle in the mammalian
immune system. Genetic ablation of the miRNA machinery, as well as loss or deregulation of
certain individual miRNAs, severely compromises immune development and response and
can lead to immune disorders like autoimmunity and cancer. Although individual miRNAs
modulate protein output from hundreds of target genes, they may impact physiological
processes by regulating the concentrations of just a few key cellular proteins that may be …
MicroRNA (miRNA) control has emerged as a critical regulatory principle in the mammalian immune system. Genetic ablation of the miRNA machinery, as well as loss or deregulation of certain individual miRNAs, severely compromises immune development and response and can lead to immune disorders like autoimmunity and cancer. Although individual miRNAs modulate protein output from hundreds of target genes, they may impact physiological processes by regulating the concentrations of just a few key cellular proteins that may be components of a single or of functionally interrelated pathways in a given cellular context.
cell.com