Effects of low-dose recombinant interleukin 2 to promote T-regulatory cells in alopecia areata
E Castela, F Le Duff, C Butori, M Ticchioni… - JAMA …, 2014 - jamanetwork.com
Importance An impaired inhibitory function of circulating CD4+ CD25+ regulatory T (Treg)
cells was reported to play a key role in alopecia areata (AA). We report the first use to our
knowledge of low-dose interleukin 2 for treating severe AA by promoting the recruitment of
Treg cells. Observations We conducted a prospective open pilot study in 5 patients with
severe AA resistant to previous systemic treatments. Subcutaneous interleukin 2 (1.5 million
IU/d) was administered during 5 days, followed by three 5-day courses of 3 million IU/d at …
cells was reported to play a key role in alopecia areata (AA). We report the first use to our
knowledge of low-dose interleukin 2 for treating severe AA by promoting the recruitment of
Treg cells. Observations We conducted a prospective open pilot study in 5 patients with
severe AA resistant to previous systemic treatments. Subcutaneous interleukin 2 (1.5 million
IU/d) was administered during 5 days, followed by three 5-day courses of 3 million IU/d at …