Cells in the pituitary that synthesize luteinizing and follicle-stimulating hormones regulate
the relative production of these two key reproductive hormones in response to signals from
the hypothalamus. These signals are encoded in the frequency of gonadotrophin-releasing-
hormone pulses. In vitro experiments with a murine-derived cell line have identified key
elements of the processes that decode the signal to regulate transcription of the subunits
encoding these hormones. The mathematical model described in this paper is based on the …