Role of mammalian target of rapamycin signaling in compensatory renal hypertrophy
JK Chen, J Chen, EG Neilson… - Journal of the American …, 2005 - journals.lww.com
Loss of functioning nephrons stimulates the growth of residual kidney tissue to augment
work capacity and maintain normal renal function. This growth largely occurs by hypertrophy
rather than from hyperplasia of the remaining nephrons. The signaling mechanisms that
increase RNA and protein synthesis during compensatory renal hypertrophy are unknown.
This study found that the remaining kidney hypertrophied 42% by 16 d after unilateral
nephrectomy (UNX) in DBA/2 mice. Immunoblotting analysis revealed increased …
work capacity and maintain normal renal function. This growth largely occurs by hypertrophy
rather than from hyperplasia of the remaining nephrons. The signaling mechanisms that
increase RNA and protein synthesis during compensatory renal hypertrophy are unknown.
This study found that the remaining kidney hypertrophied 42% by 16 d after unilateral
nephrectomy (UNX) in DBA/2 mice. Immunoblotting analysis revealed increased …