[HTML][HTML] Negative regulation of AMP-activated protein kinase (AMPK) activity by macrophage migration inhibitory factor (MIF) family members in non-small cell lung …
SE Brock, BE Rendon, K Yaddanapudi… - Journal of Biological …, 2012 - ASBMB
AMP-activated protein kinase (AMPK) is a nutrient-and metabolic stress-sensing enzyme
activated by the tumor suppressor kinase, LKB1. Because macrophage migration inhibitory
factor (MIF) and its functional homolog, d-dopachrome tautomerase (d-DT), have
protumorigenic functions in non-small cell lung carcinomas (NSCLCs) but have AMPK-
activating properties in nonmalignant cell types, we set out to investigate this apparent
paradox. Our data now suggest that, in contrast to MIF and d-DTs AMPK-activating …
activated by the tumor suppressor kinase, LKB1. Because macrophage migration inhibitory
factor (MIF) and its functional homolog, d-dopachrome tautomerase (d-DT), have
protumorigenic functions in non-small cell lung carcinomas (NSCLCs) but have AMPK-
activating properties in nonmalignant cell types, we set out to investigate this apparent
paradox. Our data now suggest that, in contrast to MIF and d-DTs AMPK-activating …