The role of p53 in hypoxia-induced apoptosis
EM Hammond, AJ Giaccia - Biochemical and biophysical research …, 2005 - Elsevier
EM Hammond, AJ Giaccia
Biochemical and biophysical research communications, 2005•ElsevierHypoxia represents one of the most physiologically relevant stresses, having significant
roles in both normal development and malignant progression. Exposure to severe hypoxia
leads to the accumulation of p53 which can in turn lead to rapid apoptosis. In contrast to the
response to DNA-damaging agents, hypoxia-induced p53 has little or no transcriptional
transactivation capabilities and instead seems to function primarily as a transrepressor in
order to induce apoptosis.
roles in both normal development and malignant progression. Exposure to severe hypoxia
leads to the accumulation of p53 which can in turn lead to rapid apoptosis. In contrast to the
response to DNA-damaging agents, hypoxia-induced p53 has little or no transcriptional
transactivation capabilities and instead seems to function primarily as a transrepressor in
order to induce apoptosis.
Hypoxia represents one of the most physiologically relevant stresses, having significant roles in both normal development and malignant progression. Exposure to severe hypoxia leads to the accumulation of p53 which can in turn lead to rapid apoptosis. In contrast to the response to DNA-damaging agents, hypoxia-induced p53 has little or no transcriptional transactivation capabilities and instead seems to function primarily as a transrepressor in order to induce apoptosis.
Elsevier