[PDF][PDF] The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses

V Gaboriau-Routhiau, S Rakotobe, E Lecuyer, I Mulder… - Immunity, 2009 - cell.com
V Gaboriau-Routhiau, S Rakotobe, E Lecuyer, I Mulder, A Lan, C Bridonneau, V Rochet…
Immunity, 2009cell.com
Microbiota-induced cytokine responses participate in gut homeostasis, but the cytokine
balance at steady-state and the role of individual bacterial species in setting the balance
remain elusive. Herein, systematic analysis of gnotobiotic mice indicated that colonization by
a whole mouse microbiota orchestrated a broad spectrum of proinflammatory T helper 1
(Th1), Th17, and regulatory T cell responses whereas most tested complex microbiota and
individual bacteria failed to efficiently stimulate intestinal T cell responses. This function …
Summary
Microbiota-induced cytokine responses participate in gut homeostasis, but the cytokine balance at steady-state and the role of individual bacterial species in setting the balance remain elusive. Herein, systematic analysis of gnotobiotic mice indicated that colonization by a whole mouse microbiota orchestrated a broad spectrum of proinflammatory T helper 1 (Th1), Th17, and regulatory T cell responses whereas most tested complex microbiota and individual bacteria failed to efficiently stimulate intestinal T cell responses. This function appeared the prerogative of a restricted number of bacteria, the prototype of which is the segmented filamentous bacterium, a nonculturable Clostridia-related species, which could largely recapitulate the coordinated maturation of T cell responses induced by the whole mouse microbiota. This bacterium, already known as a potent inducer of mucosal IgA, likely plays a unique role in the postnatal maturation of gut immune functions. Changes in the infant flora may thus influence the development of host immune responses.
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