Interleukin-12 p40 gene (IL12B) 3′-untranslated region polymorphism is associated with susceptibility to atopic dermatitis and psoriasis vulgaris

Y Tsunemi, H Saeki, K Nakamura, T Sekiya… - Journal of …, 2002 - Elsevier
Interleukin-12 (IL-12) is believed to play an important role in inducing Th1-type cytokine
profiles. Atopic dermatitis (AD) and psoriasis vulgaris (PsV) are considered to be Th2 and
Th1 type disease, respectively. The IL-12 p40 subunit gene (IL12B) is located at
chromosome 5q31-33 and linkage findings of AD on 5q31 were reported. Recently single
nucleotide polymorphism (SNP)(1188A/C) of IL12B has been reported. In function, it has
been reported that this SNP is associated with IL12B mRNA expression levels. To learn …