[HTML][HTML] Suppression of long chain acyl-CoA synthetase 3 decreases hepatic de novo fatty acid synthesis through decreased transcriptional activity
SY Bu, MT Mashek, DG Mashek - Journal of Biological Chemistry, 2009 - ASBMB
Long chain acyl-CoA synthetases (ACSL) and fatty acid transport proteins (FATP) activate
fatty acids to acyl-CoAs in the initial step of fatty acid metabolism. Numerous isoforms of
ACSL and FATP exist with different tissue distribution patterns, intracellular locations, and
substrate preferences, suggesting that each isoform has distinct functions in channeling fatty
acids into different metabolic pathways. Because fatty acids, acyl-CoAs, and downstream
lipid metabolites regulate various transcription factors that control hepatic energy …
fatty acids to acyl-CoAs in the initial step of fatty acid metabolism. Numerous isoforms of
ACSL and FATP exist with different tissue distribution patterns, intracellular locations, and
substrate preferences, suggesting that each isoform has distinct functions in channeling fatty
acids into different metabolic pathways. Because fatty acids, acyl-CoAs, and downstream
lipid metabolites regulate various transcription factors that control hepatic energy …