[HTML][HTML] 67-kDa laminin receptor promotes internalization of cytotoxic necrotizing factor 1-expressing Escherichia coli K1 into human brain microvascular endothelial …
KJ Kim, JW Chung, KS Kim - Journal of Biological Chemistry, 2005 - ASBMB
Escherichia coli K1 is the most common Gram-negative organism causing meningitis, and its
invasion of human brain microvascular endothelial cells (HBMEC) is a prerequisite for
penetration into the central nervous system. We have reported previously that cytotoxic
necrotizing factor 1 (CNF1) contributes to E. coli K1 invasion of HBMEC and interacts with 37-
kDa laminin receptor precursor (37LRP) of HBMEC, which is a precursor of 67-kDa laminin
receptor (67LR). In the present study, we examined the role of 67LR in the CNF1-expressing …
invasion of human brain microvascular endothelial cells (HBMEC) is a prerequisite for
penetration into the central nervous system. We have reported previously that cytotoxic
necrotizing factor 1 (CNF1) contributes to E. coli K1 invasion of HBMEC and interacts with 37-
kDa laminin receptor precursor (37LRP) of HBMEC, which is a precursor of 67-kDa laminin
receptor (67LR). In the present study, we examined the role of 67LR in the CNF1-expressing …