[HTML][HTML] The overlapping host responses to bacterial cyclic dinucleotides
AA Abdul-Sater, A Grajkowski… - Microbes and …, 2012 - Elsevier
Macrophages respond to infection with Legionella pneumophila by the induction of
inflammatory mediators, including type I Interferons (IFN-Is). To explore whether the bacterial
second messenger cyclic 3′-5′ diguanylate (c-diGMP) activates some of these mediators,
macrophages were infected with L. pneumophila strains in which the levels of bacterial c-
diGMP had been altered. Intriguingly, there was a positive correlation between c-diGMP
levels and IFN-I expression. Subsequent studies with synthetic derivatives of c-diGMP, and …
inflammatory mediators, including type I Interferons (IFN-Is). To explore whether the bacterial
second messenger cyclic 3′-5′ diguanylate (c-diGMP) activates some of these mediators,
macrophages were infected with L. pneumophila strains in which the levels of bacterial c-
diGMP had been altered. Intriguingly, there was a positive correlation between c-diGMP
levels and IFN-I expression. Subsequent studies with synthetic derivatives of c-diGMP, and …