[PDF][PDF] Mast cells and pancreatic cancer
TC Theoharides - New England Journal of Medicine, 2008 - researchgate.net
New England Journal of Medicine, 2008•researchgate.net
Pancreatic ductal adenocarcinoma is probably the most lethal cancer, with a median
survival of less than 6 months and a 5-year survival rate of less than 5%. The cause of
pancreatic ductal adenocarcinoma is unknown, and this type of cancer resists all currently
available treatments. Increasing evidence indicates that inflammation around tumors,
including infiltration by mast cells, facilitates cancer growth, especially that of pancreatic
ductal adenocarcinoma. 1 Mast cells are derived from a unique bone marrow precursor, and …
survival of less than 6 months and a 5-year survival rate of less than 5%. The cause of
pancreatic ductal adenocarcinoma is unknown, and this type of cancer resists all currently
available treatments. Increasing evidence indicates that inflammation around tumors,
including infiltration by mast cells, facilitates cancer growth, especially that of pancreatic
ductal adenocarcinoma. 1 Mast cells are derived from a unique bone marrow precursor, and …
Pancreatic ductal adenocarcinoma is probably the most lethal cancer, with a median survival of less than 6 months and a 5-year survival rate of less than 5%. The cause of pancreatic ductal adenocarcinoma is unknown, and this type of cancer resists all currently available treatments. Increasing evidence indicates that inflammation around tumors, including infiltration by mast cells, facilitates cancer growth, especially that of pancreatic ductal adenocarcinoma. 1
Mast cells are derived from a unique bone marrow precursor, and they mature in the tissues. They are commonly known for their role in allergic and anaphylactic reactions, during which they secrete numerous vasoactive, chemoattractant, and inflammatory molecules as well as growth factors. 2 In addition to allergic triggers, mast cells participate in inflammation; they can be activated by nonallergic triggers (Fig. 1), 3 many of which are expressed by the cells of pancreatic ductal adenocarcinoma.
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