Leukocytes in mammary development and cancer
LM Coussens, JW Pollard - Cold Spring Harbor …, 2011 - cshperspectives.cshlp.org
LM Coussens, JW Pollard
Cold Spring Harbor perspectives in biology, 2011•cshperspectives.cshlp.orgLeukocytes, of both the innate and adaptive lineages, are normal cellular components of all
tissues. These important cells not only are critical for regulating normal tissue homeostasis,
but also are significant paracrine regulators of all physiologic and pathologic tissue repair
processes. This article summarizes recent insights regarding the trophic roles of leukocytes
at each stage of mammary gland development and during cancer development, with a focus
on Murids and humans.
tissues. These important cells not only are critical for regulating normal tissue homeostasis,
but also are significant paracrine regulators of all physiologic and pathologic tissue repair
processes. This article summarizes recent insights regarding the trophic roles of leukocytes
at each stage of mammary gland development and during cancer development, with a focus
on Murids and humans.
Leukocytes, of both the innate and adaptive lineages, are normal cellular components of all tissues. These important cells not only are critical for regulating normal tissue homeostasis, but also are significant paracrine regulators of all physiologic and pathologic tissue repair processes. This article summarizes recent insights regarding the trophic roles of leukocytes at each stage of mammary gland development and during cancer development, with a focus on Murids and humans.
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